Bit concerned about this

[ConcinusMan]

That's pretty bad when a biopsy / culture still won't tell you what the heck is causing it. I guess you're pretty much screwed if that didn't work.

[guidofatherof5]

I certainly wouldn't say that as it appears to have improved after the shed.. Maybe this, whatever it is has run its course.
The fact that it isn't spreading is a good sign and the fact a shed seems to improve the condition.
This is all looking at it from a "glass half full" philosophy.

[zirliz]

DSC_1041 | Flickr - Photo Sharing! DSC_1045 | Flickr - Photo Sharing! Not the best shots I know but he is a lively bugger I hope it looks better but it's hard to tell

[guidofatherof5]

I would say there is still something active going on there. Have you gotten any of the F10 ointment yet?
I would hit this thing hard. You don't want it going septic.
If you would like I will send you a small amount to Hebiclens.

[ConcinusMan]

Dang that looks like it's getting into his eye too. Eye looks damaged/infiltrated by whatever this creeping crud is. Doesn't look better at all to me. Still an active infection. Like any wound it's going to crust over and then come off at times but the problem is still there.

[d_virginiana]

Yikes! I'd say you need to nuke that with the strongest stuff you can that's safe for the snake...

Is there any way you could get a photograph of what it looks like under a microscope? I know that's a long shot, but checking it out yourself or taking a swab and growing it up on a plate would at least give you an idea if it was bacterial or fungal... I'm surprised nothing turned up when the vet checked it out, but maybe all the tissue before was dead, since it all seems to have sloughed off so easily? That could make it hard to get good biopsy results...

[ConcinusMan]

Yeah, I was thinking that if the problem is deep in the live tissue, gathering a little dead scab material from the surface for the biopsy probably wouldn't be very revealing. There has to be an agent at work and it was just missed.

[zirliz]

ive ordered that f10 ointment , when you say strongest stuff do you have an example

[d_virginiana]

Well, I don't know what anti-fungal stuff is safe for snakes, so someone else would have to give you some advice there.
If it's bacterial, then washing it out with a 50/50 solution of hydrogen peroxide and water would probably be the strongest thing I can think of... I wouldn't normally recommend that, because hydrogen peroxide can be pretty rough on the snake, but idk. In this situation I think the priority is keeping whatever this is from spreading any further.

[CrazyHedgehog]

be careful with peroxide, it is sold in much stronger concentrate in the uk!!