What I have noticed of my red-sided (Thamnophis sirtalis parietalis) is they are pretty much dog tame; not all that excitable and settle down to being held well. I've held the 8 that are from the same litter of them in one hand a number of times, and they twine my fingers and such with out any issue while I clean their enclosure with the other hand- Mind you this also means I was able to pick all 8 of them up at once. The other 6 red sided are also nice, but are not kept together so interaction ia all one on one. The ones kept separate also tend to be a little more excitable.

My Eastern (Thamnophis sirtalis sirtalis) scrubs are fairly excitable, they appear to be thinking "OMG the monster is gonna eat me!!" every time I go into the enclosure- warning strikes and scrambling to get away etc. I don't think any have ever made contact- The adults I've delt with have all been calm, friendly interested snakes. Belle-Fleur is the most eager to be handled snake I've ever had. (I've had some very friendly snakes)